Nitrofurantoin is reduced by bacterial flavoproteins to reactive intermediates which inactivate or alter bacterial ribosomal proteins and other macromolecules. The mechanism of the antimicrobial action of nitrofurantoin is unusual among antibacterials. Nitrofurantoin is a nitrofuran antimicrobial agent with activity against certain Gram-positive and Gram-negative bacteria. When nitrofurantoin monohydrate/macrocrystals capsules are administered with food, the bioavailability of nitrofurantoin is increased by approximately 40%. Nitrofurantoin is highly soluble in urine, to which it may impart a brown color. Plasma nitrofurantoin concentrations after a single oral dose of the 100 mg nitrofurantoin monohydrate/macrocrystals capsules are low, with peak levels usually less than 1 mcg/mL. Approximately 20-25% of a single dose of nitrofurantoin is recovered from the urine unchanged over 24 hours. Based on urinary pharmacokinetic data, the extent and rate of urinary excretion of nitrofurantoin from the 100 mg nitrofurantoin monohydrate/macrocrystals capsule are similar to those of the 50 mg or 100 mg nitrofurantoin macrocrystals capsule. The remaining 75% is nitrofurantoin monohydrate contained in a powder blend which, upon exposure to gastric and intestinal fluids, forms a gel matrix that releases nitrofurantoin over time. Twenty-five percent is macrocrystalline nitrofurantoin, which has slower dissolution and absorption than nitrofurantoin monohydrate. Keep from freezing.ĭo not keep outdated medicine or medicine no longer needed.Īsk your healthcare professional how you should dispose of any medicine you do not use.Each nitrofurantoin monohydrate/macrocrystals capsule contains two forms of nitrofurantoin. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. If you miss a dose of this medicine, take it as soon as possible. Infants younger than 1 month of age-Use is not recommended.įor treatment of urinary tract infections:Īdults and teenagers-50 to 100 milligrams (mg) every six hours.įor oral dosage form (extended-release capsules):Īdults, teenagers, and children 12 years of age and older-100 milligrams (mg) every twelve hours for seven days.Ĭhildren younger than 12 years of age-Use and dose must be determined by your doctor. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.įor oral dosage forms (capsules, suspension, and tablets):įor prevention of urinary tract infections:Īdults and teenagers-50 to 100 milligrams (mg) at bedtime.Ĭhildren and infants 1 month of age and older-Dose is based on body weight and must be determined by your doctor. The amount of medicine that you take depends on the strength of the medicine. If your dose is different, do not change it unless your doctor tells you to do so. The following information includes only the average doses of this medicine. Follow your doctor's orders or the directions on the label. The dose of this medicine will be different for different patients. It may prevent the medicine from working properly. Do not open, crush, or chew the capsule before swallowing it.ĭo not take antacids containing magnesium trisilicate (e.g., Genaton®) while you are using nitrofurantoin. The average household teaspoon may not hold the right amount of liquid. Use a specially marked measuring spoon or other device to measure each dose accurately. Shake the oral liquid forcefully before each dose to make sure the medicine is evenly mixed. To help clear up your infection completely, keep taking this medicine for the full time of treatment, even if you begin to feel better after a few days. This may lessen stomach upset and help your body to absorb the medicine. Nitrofurantoin is best taken with food or milk.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |